Skin pigment pattern formation is a paradigmatic example of pattern formation. In zebrafish, the adult body stripes are generated by coordinated rearrangement of three distinct pigment cell‐types, black melanocytes, shiny iridophores and yellow xanthophores. A stem cell origin of melanocytes and iridophores has been proposed although the potency of those stem cells has remained unclear. Xanthophores, however, seemed to originate predominantly from proliferation of embryonic xanthophores. Now, data from Singh et al. shows that all three cell‐types derive from shared stem (...) cells, and that these cells generate peripheral neural cell‐types too. Furthermore, clonal compositions are best explained by a progressive fate restriction model generating the individual cell‐types. The numbers of adult pigment stem cells associated with the dorsal root ganglia remain low, but progenitor numbers increase significantly during larval development up to metamorphosis, likely via production of partially restricted progenitors on the spinal nerves. (shrink)

C. Fred Alford contends that the manner in which I objected to Feyerabend's democratic relativism is vulnerable to Feyerabend's rhetorical strategy, and that a better strategy would be to show that Feyerabend fails to demonstrate that democratic relativism is desirable. I reply in defense of the ?plausibility? issue on the grounds that Feyerabend's theory lends itself to uses (and abuses) beyond Utopian critique (in Alford's sense). I argue that it is the fact that critics ? myself included ? have assumed (...) the burden of demonstrating the impossibility of Feyerabend's political theory that has led to the stalemate Alford describes, and that we may retain the ?plausibility? question while avoiding the stalemate by placing the burden of argument on Feyerabend to show that his theory is plausible. (shrink)

Stephen Yates's objections to Feyerabend's political theory (Inquiry 27 [1984], 137?42) are presented in a way that makes them unnecessarily vulnerable to a rhetorical strategy often employed by Feyerabend. Like many other critics, Yates seems to assume that it is the implausibility of Feyerabend's claims that opens them to refutation, whereas it is really this that makes them such slippery targets of criticism. Rather than claim that Feyerabend's ideal would be virtually impossible to realize, I argue that Feyerabend (...) does not demonstrate why ?democratic relativism? is at all desirable. (shrink)

"As a doctor, I make every effort to strengthen the belief in immortality, especially with older patients when such questions come threateningly close. For, seen in correct psychological perspective, death is not an end but a goal, and life's inclination towards death begins as soon as the meridian is past."--C.G. Jung, commentary on The Secret of the Golden FlowerHere collected for the first time are Jung's views on death and immortality, his writings often coinciding with the death of the most (...) significant people in his life. The book shows many of the major themes running throughout the writings, including the relativity of space and time surrounding death, the link between transference and death, and the archetypes shared among the world's religions at the depths of the Self. The book includes selections from "On Resurrection," "The Soul and Death," "Concerning Rebirth," "Psychological Commentary on The Tibetan Book of the Dead" from the Collected Works, "Letter to Pastor Pfafflin" from Letters, and "On Life after Death.". (shrink)

Peut-on prédire si un projet sera jugé socialement acceptable par ses principales parties prenantes? Dans un contexte où l’acceptabilité sociale en est venue à être considérée comme une condition à la réalisation de tout grand projet, cette question s’avère centrale pour tout développeur de projet, de même que pour les investisseurs qui les soutiennent. C’est dans cette perspective qu’a été développé l’Indice du risque social dans les projets miniers, une initiative soutenue par l’Autorité des marchés financiers à laquelle a travaillé (...) une équipe interdisciplinaire de chercheurs. Au-delà de jeter un éclairage sur la pertinence d’aller de l’avant ou non avec un projet, cet outil prédictif peut surtout permettre de moduler ledit projet, de concert avec ses parties prenantes, pour le rendre davantage acceptable à leurs yeux. Nous souhaitons ici rendre compte des possibilités offertes par cet indice en l’appliquant à deux projets miniers récemment discutés au Québec, soit le projet de mine aurifère développé par Osisko dans la municipalité de Malartic, en Abitibi-Témiscamingue, et celui de Mine Arnaud, à Sept-Îles, qui vise cette fois l’exploitation de l’apatite. Cet exercice nous permet de réaffirmer la pertinence de l’outil que constitue l’Indice, mais également de relever les limites qui lui sont inhérentes. (shrink)

Peut-on prédire si un projet sera jugé socialement acceptable par ses principales parties prenantes? Dans un contexte où l’acceptabilité sociale en est venue à être considérée comme une condition à la réalisation de tout grand projet, cette question s’avère centrale pour tout développeur de projet, de même que pour les investisseurs qui les soutiennent. C’est dans cette perspective qu’a été développé l’Indice du risque social dans les projets miniers, une initiative soutenue par l’Autorité des marchés financiers à laquelle a travaillé (...) une équipe interdisciplinaire de chercheurs. Au-delà de jeter un éclairage sur la pertinence d’aller de l’avant ou non avec un projet, cet outil prédictif peut surtout permettre de moduler ledit projet, de concert avec ses parties prenantes, pour le rendre davantage acceptable à leurs yeux. Nous souhaitons ici rendre compte des possibilités offertes par cet indice en l’appliquant à deux projets miniers récemment discutés au Québec, soit le projet de mine aurifère développé par Osisko dans la municipalité de Malartic, en Abitibi-Témiscamingue, et celui de Mine Arnaud, à Sept-Îles, qui vise cette fois l’exploitation de l’apatite. Cet exercice nous permet de réaffirmer la pertinence de l’outil que constitue l’Indice, mais également de relever les limites qui lui sont inhérentes. (shrink)

The relative indifference to Kant's interpretation of aesthetics and teleology can no doubt be accounted for in several ways. Partly, it is simply that the natural approach to Kant is to begin with the Prolegomena, and then depending on one's interests, to move directly to Kant's treatment of the problem of knowledge or ethical action--thereby leaving Kant's independent analysis of judgment for last, if at all. Moreover, it is impossible to grasp the complexity of the problem of judgment without a (...) substantial understanding of Kant's first two inquiries. (shrink)

Purpose: Explore public attitudes towards the trade-offs between justice and medical outcome inherent in organ allocation decisions.Background: The US Task Force on Organ Transplantation recommended that considerations of justice, autonomy and medical outcome be part of all organ allocation decisions. Justice in this context may be modeled as a function of three types of need, related to age, clinical urgency, and quality of life.Methods: A web-based survey was conducted in which respondents were asked to choose between two hypothetical patients who (...) differed in clinical urgency , age, pretransplant and post-transplant quality of life, and life expectancy.Results: A pool of 1600 people were notified via email about the survey; 623 responded. Respondents preferred giving organs to younger people up to an age difference of <15.4 years and more clinically urgent people up to a difference in urgency of <2.54 months . Priority varied with the quality of life of the worst-off patient and the relative status of the patients. If both had worse than average quality of life, respondents preferred the better-off patient. When both had better than average quality of life, they preferred the worse-off patient. In analysis according to age versus clinical urgency, the older the patient, the more urgency needed to receive priority. In quality of life versus clinical urgency, the better the control’s quality of life, the more urgency the competing patient required. The worse the patient’s post-transplant outcome, the more urgency needed to receive priority.Conclusions: It appears that clinical urgency is only one of many factors influencing attitudes about allocation decisions and that respondents may invoke different principles of fairness depending the relative clinical status of patients. (shrink)

It will be best to explain here, at the start, that I do not propose new etymologies for the words εὒξεινος and πόντος. I regard, then, εὒξεινος πόντος as meaning ‘the hospitable way’. My purpose is to show how such a name came to be given to the Black Sea by the Greeks. First, the word πόντος. The familiar explanation connects it with a series of words, of which I give the most important: Gk. πάτος ‘trodden path’; Skt. pάnthā ‘way’, (...) fem. pathyā ‘id.’; Zend paθ ‘id.’; Arm. hun ‘ford, road’; Lat. pons ‘bridge’. Further, as a verb the root appears in Gk. πατεν ‘tread down’ and is given in Walde-Pokorny as *pent- ‘tread, go’: W.-P. points out that the derived nouns mean ‘way’, and particularly a way that goes over or through water, as can be seen from the Armenian and Latin. (shrink)

The paper attempts to do the following: (1) provide a reconstruction of a valid argument for Frege’s thesis that a truth-apt sentence refers to its truth value---an argument that is the implicit argument of Frege’s original text, based on premises explicitly stated or clearly implied in “On Sense and Reference”; (2) examine a standard version (essentially Davidson’s) of the recent counterpart of the Fregean Argument (the so-called Slingshot) designed to refute, quite generally, fact-based correspondence theories of truth; and (3) show (...) exactly why Wittgenstein’s correspondence theory in the Tractatus is not subject to the Slingshot Argument. If so, then, contra Davidson, it is neither the case that a correspondence theory need be nonexplanatory of truth, nor the case that a “strategy of facts” cannot be sustained. Indeed, for Wittgenstein, the Slingshot cannot even come into play, unless we attempt to say what can only be shown. (shrink)

The root *pent-1 has achieved wide distribution in the IE. languages. In the course of its long history considerable modification of meaning has affected it, both as a primary verb and as it appears in derivative nouns, and here I refer particularly to Go. finpan ‘find’ and to Gk. πάτη ‘deceit’. With little ingenuity—against mere ingenuity, of course, the etymologist is bound to be on his guard—it is possible to trace the train of thought that connects the various forms. But (...) though the explanations here offered may well seem obvious, they have not, so far as I am aware, been previously published. The familiar dictionaries of Boisacq, Walde-Hofmann, and Walde-Pokorny do provide attempts at explanation, but these have little power of convincing. (shrink)

Etymology, especially that of an ancient language like Greek, is not as a rule a field in which one expects to get conclusive demonstration; and between rival explanations one is often provided with a choice which cannot be made with much confidence. But despite this I think that I should reply to the article by W. S. Allen on ‘The Name of the Black Sea in Greek’ , pp. 86–8), which has raised again the question dealt with in my article (...) ‘The Name of the Euxine Pontus’ , pp. 123–8). This is not so much because I do not feel satisfied with Allen's explanation , as because this particular etymology has considerable historical, in addition to linguistic, interest. (shrink)

The question of the source of the pronominal forms , and of the later fully declined forms, presents an unusual situation. It seems clear from earlier work that we should not look for the answer outside Greek, nor probably even outside colloquial Attic Greek of the fifth century. These are strong advantages, but despite them one cannot have much confidence in the solutions so far provided, and there is room for a fresh approach. In addition to this, the usage of (...) the forms does not seem to have been explained satisfactorily, and I shall attempt to clarify it. (shrink)